The Pio Monte della Misericordia is a charitable Institution, still active, established in 1602 by seven Neapolitan noblemen. The 17th-century palace, designed by Francesco Antonio Picchiatti, holds one of the most important private collections open to the public: in the picture gallery on the first floor, are exposed, as well as the prestigious collection donated by 18th century painter Francesco De Mura, works from the 16th to the 19th century including Giordano, Ribera, Sam, Vaccaro, Priests and other important masters. The apartment offers a historical very suggestive path characterized by a production House-Museum which has a dual function: the environments are, at the same time, the exhibition space open to the public and private association, which still uses these precious rooms in order to carry out its functions. Hosting environments even objets d'art, silverware and vestments from ancient Neapolitan Fraternities (Real company and White archconfraternity of Holy Spirit confraternity and Mount Royal, of SS. Sacramento Spanish nobles, Opera Pia Holy Temple of Scorziata, etc.)
Of considerable importance is the painting by Caravaggio, "The seven works of mercy" (1607), placed at the Church altar. Other altars, depicting individual works of mercy carried out by the institution, are the paintings by Luca Giordano, Fabrizio Santafede is preserved, Battistello Caracciolo, Giovan Bernardo Azzolino and Giovan Vincenzo Forlì.
From 2008 is on the first floor, with temporary exhibitions, the art collection of the province of Naples which boasts important Neapolitan masterpieces from the 19th and 20th centuries.
The seat of the Pio Monte della Misericordia also houses an archive/library especially valuable for the quantity and rarity of the documents and the volumes in it.